Walking past the beautiful Bank of England building one day, I was reminded of a curious principle named after Charles Goodhart, a former advisor to the Bank of England. In 1975, he formulated a rule now known as Goodhart's Law: "Any observed statistical regularity tends to break down once pressure is applied to it for control purposes." In essence, when we set a target to achieve a certain metric, the old patterns that once made that metric meaningful stop working. Simply put, "when a measure becomes a target, it ceases to be a good measure." Epigenetic age: When we replace hard endpoints in research with biomarkers, we risk making critical errors. For example, epigenetic age can be reduced by taking vitamin D, growth hormone, folate (B9), B12, and consuming certain foods (like poultry). However, none of these interventions reduce mortality or extend lifespan. The Vitamin D paradox: High levels of vitamin D in the blood are strongly linked to lower risks...
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